Chemoenzymatic conversion of amides to enantioenriched alcohols in aqueous medium

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Conversion of Alcohols into Amides Using Alumina-Methanesulfonic Acid (AMA) in Nitrile Solvents

The reaction of tertiary, secondary and benzylic alcohols with different nitriles in the presence of alumina-methanesulfonic acid (AMA) as a new reagent affords the corresponding amides in good yields (Table 1, 2). Conversion of 2,6-bis(hydroxymethyl)-4-halo anisoles into corresponding diamides in the range of 68-76% yields (Table 3) are also included in this paper.

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conversion of alcohols into amides using alumina-methanesulfonic acid (ama) in nitrile solvents

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ژورنال

عنوان ژورنال: Communications Chemistry

سال: 2019

ISSN: 2399-3669

DOI: 10.1038/s42004-019-0182-8